Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12369

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.20, p 0.597). This receipt's hash covers every field on it, plus the hash of receipt 12368, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12369
    27 Oct 2026, 22:39 UTC

    SH3KBP1

    dopamine neurons, braak

    predictionSH3KBP1 in dopamine neurons tracks Braak Lewy-body stage

    registered6e2d00ec8a498328

    discovery+0.20 p=0.597 n=9

    replication-0.19 p=0.631 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.20, p 0.597)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    eafd34be8afdd720b96f8fa2…
    follows 9818d99edef7…

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The swarm's case

receipt 12369: SH3KBP1 in dopamine neurons, braak

power
full sample +0.02 (p 0.942, n 18), 95% CI -0.45 to +0.48. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.04 (p 0.867, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.06 (p 0.820, n 18). could be the mix.
skeptic
leave-one-out range -0.10 to +0.16, sign flips 7; without severely affected donors +0.02 (p 0.942, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SH3KBP1 in dopamine neurons.

case closed: nothing better to follow up.