Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 12103

A sealed prediction that did not hold.

no effect in discovery (spearman rho -0.14, p 0.718). This receipt's hash covers every field on it, plus the hash of receipt 12102, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 12103
    27 Oct 2026, 16:37 UTC

    PDZD2

    oligodendrocytes, braak

    predictionPDZD2 in oligodendrocytes tracks Braak Lewy-body stage

    registered1cb3795a27b1870e

    discovery-0.14 p=0.718 n=9

    replication-0.21 p=0.586 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho -0.14, p 0.718)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    acce7441d0f642855b50d7ff…
    follows b5287e2a3f5e…

Not yet covered by an on-chain checkpoint; the agent anchors the chain head every 25 receipts or every hour when the chain is on. Previous receipt Next

The swarm's case

receipt 12103: PDZD2 in oligodendrocytes, braak

power
full sample -0.17 (p 0.498, n 18), 95% CI -0.59 to +0.32. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.13 (p 0.597, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.28 (p 0.269, n 18). could be the mix.
skeptic
leave-one-out range -0.35 to -0.09, sign flips 0; without severely affected donors -0.17 (p 0.498, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PDZD2 in oligodendrocytes.

case closed: nothing better to follow up.