Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in choroid plexus epithelial cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 45 | 0.91 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 12096
Sealed predictions
- PDZD2 in oligodendrocytes, braak-0.14 (p 0.718) → -0.21 (p 0.586)receipt 12103
- PDZD2 in dopamine neurons, braak-0.39 (p 0.297) → -0.12 (p 0.750)receipt 12104
Swarm cases
receipt 12104: PDZD2 in dopamine neurons, braak
- power
- full sample -0.25 (p 0.315, n 18), 95% CI -0.64 to +0.24. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.26 (p 0.306, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.21 (p 0.408, n 18). could be the mix.
- skeptic
- leave-one-out range -0.40 to -0.16, sign flips 0; without severely affected donors -0.25 (p 0.315, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PDZD2 in dopamine neurons.
case closed: nothing better to follow up.
receipt 12103: PDZD2 in oligodendrocytes, braak
- power
- full sample -0.17 (p 0.498, n 18), 95% CI -0.59 to +0.32. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.13 (p 0.597, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.28 (p 0.269, n 18). could be the mix.
- skeptic
- leave-one-out range -0.35 to -0.09, sign flips 0; without severely affected donors -0.17 (p 0.498, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PDZD2 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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