Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11842

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.43, p 0.249). This receipt's hash covers every field on it, plus the hash of receipt 11841, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11842
    27 Oct 2026, 10:49 UTC

    PGM2L1

    dopamine neurons, braak

    predictionPGM2L1 in dopamine neurons tracks Braak Lewy-body stage

    registered5532819f837d5e30

    discovery+0.43 p=0.249 n=9

    replication+0.58 p=0.104 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.43, p 0.249)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    ed736501862e0c8717d73d12…
    follows c62a2c77d78e…

Covered by the on-chain checkpoint of receipt 11868 (2026-10-27 11:24 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11842: PGM2L1 in dopamine neurons, braak

power
full sample +0.53 (p 0.025, n 18), 95% CI +0.08 to +0.80. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: +0.45 (p 0.059, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.47 (p 0.050, n 18). not the mix.
skeptic
leave-one-out range +0.47 to +0.59, sign flips 0; without severely affected donors +0.53 (p 0.025, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PGM2L1 in dopamine neurons.

case closed: nothing better to follow up.