Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 11834
Sealed predictions
- PGM2L1 in dopamine neurons, braak+0.43 (p 0.249) → +0.58 (p 0.104)receipt 11842
Swarm cases
receipt 11842: PGM2L1 in dopamine neurons, braak
- power
- full sample +0.53 (p 0.025, n 18), 95% CI +0.08 to +0.80. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.45 (p 0.059, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.47 (p 0.050, n 18). not the mix.
- skeptic
- leave-one-out range +0.47 to +0.59, sign flips 0; without severely affected donors +0.53 (p 0.025, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PGM2L1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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