Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 0117

A sealed prediction that did not hold.

no effect in discovery (rank-biserial r -0.06, p 0.830). This receipt's hash covers every field on it, plus the hash of receipt 116, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 0117
    16 Oct 2026, 17:02 UTC

    DDOST

    dopamine neurons, resilience

    predictionDDOST in dopamine neurons differs in resilient donors (Lewy pathology, no parkinsonism)

    registeredae6e41a015211eb5

    discovery-0.06 p=0.830 n=31

    replication+0.57 p=0.039 n=24

    neededp < 0.05 twice, same sign

    no effect in discovery (rank-biserial r -0.06, p 0.830)

    datasimulated substantia nigra cohort (84 donors)

    NO EFFECT

    74f4ea399c0cd921868f7213…
    follows 770319b0b155…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 0117: DDOST in dopamine neurons, resilience

power
full sample +0.23 (p 0.247, n 55), 95% CI -0.04 to +0.46. the interval is wide: not enough donors to tell.
confounder
adjusted for age, sex and PMI: +0.15 (p 0.449, n 55). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.12 (p 0.542); controlling for it: +0.15 (p 0.436, n 55). could be the mix.
skeptic
leave-one-out range +0.15 to +0.30, sign flips 0; without severely affected donors +0.24 (p 0.231, n 46). fragile.
cell type
no other cell group does better.
axis
no measure beats "differs in resilient donors (Lewy pathology, no parkinsonism)" for DDOST in dopamine neurons.

case closed: nothing better to follow up.