Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11650

A sealed prediction that did not hold.

did not replicate (discovery -0.77 p 0.015; held-out +0.19 p 0.630). This receipt's hash covers every field on it, plus the hash of receipt 11649, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11650
    27 Oct 2026, 06:32 UTC

    ADARB2

    oligodendrocytes, braak

    predictionADARB2 in oligodendrocytes tracks Braak Lewy-body stage

    registereda66bd0e184ff41f5

    discovery-0.77 p=0.015 n=9

    replication+0.19 p=0.630 n=9

    neededp < 0.05 twice, same sign

    did not replicate (discovery -0.77 p 0.015; held-out +0.19 p 0.630)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    DID NOT REPLICATE

    16516c7dbac8b75d7fee89b1…
    follows a364e0102f40…

Covered by the on-chain checkpoint of receipt 11658 (2026-10-27 06:43 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11650: ADARB2 in oligodendrocytes, braak

power
full sample -0.51 (p 0.032, n 18), 95% CI -0.79 to -0.05. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.52 (p 0.027, n 18). holds up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.51 (p 0.032, n 18). not the mix.
skeptic
leave-one-out range -0.64 to -0.45, sign flips 0; without severely affected donors -0.51 (p 0.032, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ADARB2 in oligodendrocytes.

case closed: nothing better to follow up.