Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

ADARB2

adenosine deaminase RNA specific B2 (inactive)

translation score 0.43, read 2026-10-27; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced in oligodendrocyte progenitor cells (1296 nCPM)1.00
chemistry
Open Targets		hard to drug0.00
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		1 Parkinson's papers of 550.91
pathways
Reactome		in no curated pathway0.00

No case: the score is under the bar. Receipt 11642

Sealed predictions

  1. ADARB2 in oligodendrocytes, braak-0.77 (p 0.015) → +0.19 (p 0.630)receipt 11650
  2. ADARB2 in dopamine neurons, braak-0.16 (p 0.685) → -0.30 (p 0.435)receipt 11651

Swarm cases

receipt 11651: ADARB2 in dopamine neurons, braak

power
full sample -0.29 (p 0.243, n 18), 95% CI -0.67 to +0.20. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.36 (p 0.145, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.44 (p 0.064, n 18). could be the mix.
skeptic
leave-one-out range -0.40 to -0.21, sign flips 0; without severely affected donors -0.29 (p 0.243, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ADARB2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 11650: ADARB2 in oligodendrocytes, braak

power
full sample -0.51 (p 0.032, n 18), 95% CI -0.79 to -0.05. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.52 (p 0.027, n 18). holds up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.51 (p 0.032, n 18). not the mix.
skeptic
leave-one-out range -0.64 to -0.45, sign flips 0; without severely affected donors -0.51 (p 0.032, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ADARB2 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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