Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11477

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.37, p 0.324). This receipt's hash covers every field on it, plus the hash of receipt 11476, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11477
    27 Oct 2026, 02:35 UTC

    IL23R

    dopamine neurons, braak

    predictionIL23R in dopamine neurons tracks Braak Lewy-body stage

    registered9e7d01cc5c19050c

    discovery+0.37 p=0.324 n=9

    replication+0.59 p=0.092 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.37, p 0.324)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    864bf3e86ac637e21b9254e2…
    follows 4042498a18bc…

Covered by the on-chain checkpoint of receipt 11499 (2026-10-27 03:07 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11477: IL23R in dopamine neurons, braak

power
full sample +0.61 (p 0.0067, n 18), 95% CI +0.21 to +0.84. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: +0.64 (p 0.0040, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.68 (p 0.0021, n 18). not the mix.
skeptic
leave-one-out range +0.56 to +0.74, sign flips 0; without severely affected donors +0.61 (p 0.0067, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for IL23R in dopamine neurons.

case closed: nothing better to follow up.