Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (innate lymphoid cells) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 1,381 | 0.91 |
| pathways Reactome | 2 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 11439
Sealed predictions
- IL23R in dopamine neurons, braak+0.37 (p 0.324) → +0.59 (p 0.092)receipt 11477
Swarm cases
receipt 11477: IL23R in dopamine neurons, braak
- power
- full sample +0.61 (p 0.0067, n 18), 95% CI +0.21 to +0.84. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.64 (p 0.0040, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.68 (p 0.0021, n 18). not the mix.
- skeptic
- leave-one-out range +0.56 to +0.74, sign flips 0; without severely affected donors +0.61 (p 0.0067, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for IL23R in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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