Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11325

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.02, p 0.964). This receipt's hash covers every field on it, plus the hash of receipt 11324, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11325
    26 Oct 2026, 23:54 UTC

    TUB

    dopamine neurons, braak

    predictionTUB in dopamine neurons tracks Braak Lewy-body stage

    registered5c26bfded336e2ee

    discovery+0.02 p=0.964 n=9

    replication-0.45 p=0.230 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.02, p 0.964)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    00c4edde2f753b60ae9c0c14…
    follows b7cb7112b31a…

Covered by the on-chain checkpoint of receipt 11347 (2026-10-27 00:25 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11325: TUB in dopamine neurons, braak

power
full sample -0.22 (p 0.374, n 18), 95% CI -0.62 to +0.27. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.21 (p 0.398, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.38 (p 0.118, n 18). could be the mix.
skeptic
leave-one-out range -0.37 to -0.11, sign flips 0; without severely affected donors -0.22 (p 0.374, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TUB in dopamine neurons.

case closed: nothing better to follow up.