Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11301

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.47, p 0.197). This receipt's hash covers every field on it, plus the hash of receipt 11300, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11301
    26 Oct 2026, 23:20 UTC

    UBE2D3

    dopamine neurons, braak

    predictionUBE2D3 in dopamine neurons tracks Braak Lewy-body stage

    registered027e6cb7f9d69d65

    discovery+0.47 p=0.197 n=9

    replication+0.11 p=0.770 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.47, p 0.197)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    43c9b752a44664e3f336a6db…
    follows cfd6b12c4104…

Covered by the on-chain checkpoint of receipt 11319 (2026-10-26 23:45 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11301: UBE2D3 in dopamine neurons, braak

power
full sample +0.32 (p 0.201, n 18), 95% CI -0.18 to +0.68. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.34 (p 0.164, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.48 (p 0.045, n 18). not the mix.
skeptic
leave-one-out range +0.23 to +0.44, sign flips 0; without severely affected donors +0.32 (p 0.201, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for UBE2D3 in dopamine neurons.

case closed: nothing better to follow up.