Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 11044

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.31, p 0.411). This receipt's hash covers every field on it, plus the hash of receipt 11043, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 11044
    26 Oct 2026, 17:19 UTC

    CH25H

    dopamine neurons, braak

    predictionCH25H in dopamine neurons tracks Braak Lewy-body stage

    registeredb73dab4e2fb54700

    discovery+0.31 p=0.411 n=9

    replication+0.68 p=0.046 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.31, p 0.411)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    9bb39285c263697e95705897…
    follows f928ef1bbdfe…

Covered by the on-chain checkpoint of receipt 11050 (2026-10-26 17:29 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 11044: CH25H in dopamine neurons, braak

power
full sample +0.41 (p 0.091, n 18), 95% CI -0.07 to +0.74. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.35 (p 0.159, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.34 (p 0.173, n 18). could be the mix.
skeptic
leave-one-out range +0.35 to +0.59, sign flips 0; without severely affected donors +0.41 (p 0.091, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CH25H in dopamine neurons.

case closed: nothing better to follow up.