parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in vascular smooth muscle cells	0.75
chemistry Open Targets	reachable by antibody	0.36
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 323	0.82
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 11036

CH25H in dopamine neurons, braak+0.31 (p 0.411) → +0.68 (p 0.046)receipt 11044
CH25H in microglia, braak+0.74 (p 0.024) → -0.61 (p 0.083)receipt 11043

receipt 11044: CH25H in dopamine neurons, braak

power: full sample +0.41 (p 0.091, n 18), 95% CI -0.07 to +0.74. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.35 (p 0.159, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.34 (p 0.173, n 18). could be the mix.
skeptic: leave-one-out range +0.35 to +0.59, sign flips 0; without severely affected donors +0.41 (p 0.091, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CH25H in dopamine neurons.

case closed: nothing better to follow up.

receipt 11043: CH25H in microglia, braak

power: full sample +0.11 (p 0.664, n 18), 95% CI -0.38 to +0.55. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.19 (p 0.444, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.20 (p 0.424, n 18). could be the mix.
skeptic: leave-one-out range -0.02 to +0.27, sign flips 1; without severely affected donors +0.11 (p 0.664, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CH25H in microglia.

case closed: nothing better to follow up.

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