Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10979

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.15, p 0.697). This receipt's hash covers every field on it, plus the hash of receipt 10978, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10979
    26 Oct 2026, 15:46 UTC

    GPRIN2

    dopamine neurons, braak

    predictionGPRIN2 in dopamine neurons tracks Braak Lewy-body stage

    registered597b97f59e28ffb7

    discovery+0.15 p=0.697 n=9

    replication-0.76 p=0.017 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.15, p 0.697)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    455a257be6b291eb1881a699…
    follows 693ff359c67b…

Covered by the on-chain checkpoint of receipt 10998 (2026-10-26 16:18 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10979: GPRIN2 in dopamine neurons, braak

power
full sample -0.32 (p 0.194, n 18), 95% CI -0.69 to +0.17. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.35 (p 0.159, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.54 (p 0.020, n 18). not the mix.
skeptic
leave-one-out range -0.48 to -0.24, sign flips 0; without severely affected donors -0.32 (p 0.194, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for GPRIN2 in dopamine neurons.

case closed: nothing better to follow up.