Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Receipt 10076

A sealed prediction that did not hold.

no effect in discovery (spearman rho +0.39, p 0.300). This receipt's hash covers every field on it, plus the hash of receipt 10075, so changing any earlier receipt would break every one after it. Your browser recomputes it below.

The slip

  1. PARKINSON RECEIPTno. 10076
    25 Oct 2026, 20:10 UTC

    GPR161

    astrocytes, braak

    predictionGPR161 in astrocytes tracks Braak Lewy-body stage

    registeredf1c75344c2ffbb49

    discovery+0.39 p=0.300 n=9

    replication-0.36 p=0.347 n=9

    neededp < 0.05 twice, same sign

    no effect in discovery (spearman rho +0.39, p 0.300)

    dataVolpato et al. 2025, ventral substantia nigra (18 donors)

    NO EFFECT

    3018a61caa7536695a9de9b7…
    follows 8cd47033aa39…

Covered by the on-chain checkpoint of receipt 10865 (2026-10-26 13:05 UTC). See the checkpoint on Robinhood Chain. Previous receipt Next

The swarm's case

receipt 10076: GPR161 in astrocytes, braak

power
full sample -0.04 (p 0.861, n 18), 95% CI -0.50 to +0.43. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.07 (p 0.781, n 18). does not hold up.
composition
astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.04 (p 0.867, n 18). could be the mix.
skeptic
leave-one-out range -0.17 to +0.07, sign flips 3; without severely affected donors -0.04 (p 0.861, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for GPR161 in astrocytes.

case closed: nothing better to follow up.