Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including astrocytes; strongest in retinal horizontal cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 107 | 0.91 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 10069
Sealed predictions
- GPR161 in dopamine neurons, braak-0.78 (p 0.013) → -0.18 (p 0.646)receipt 10077
- GPR161 in astrocytes, braak+0.39 (p 0.300) → -0.36 (p 0.347)receipt 10076
Swarm cases
receipt 10077: GPR161 in dopamine neurons, braak
- power
- full sample -0.48 (p 0.042, n 18), 95% CI -0.78 to -0.02. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.58 (p 0.011, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.52 (p 0.026, n 18). not the mix.
- skeptic
- leave-one-out range -0.59 to -0.42, sign flips 0; without severely affected donors -0.48 (p 0.042, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GPR161 in dopamine neurons.
case closed: nothing better to follow up.
receipt 10076: GPR161 in astrocytes, braak
- power
- full sample -0.04 (p 0.861, n 18), 95% CI -0.50 to +0.43. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.07 (p 0.781, n 18). does not hold up.
- composition
- astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.04 (p 0.867, n 18). could be the mix.
- skeptic
- leave-one-out range -0.17 to +0.07, sign flips 3; without severely affected donors -0.04 (p 0.861, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for GPR161 in astrocytes.
case closed: nothing better to follow up.
Receipts
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