Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in myonuclei | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 7982
Sealed predictions
- ZNF638 in dopamine neurons, braak+0.14 (p 0.725) → -0.06 (p 0.874)receipt 7990
- ZNF638 in oligodendrocytes, braak-0.07 (p 0.857) → +0.32 (p 0.407)receipt 7989
Swarm cases
receipt 7990: ZNF638 in dopamine neurons, braak
- power
- full sample -0.01 (p 0.962, n 18), 95% CI -0.48 to +0.46. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.01 (p 0.962, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.07 (p 0.794, n 18). could be the mix.
- skeptic
- leave-one-out range -0.15 to +0.07, sign flips 12; without severely affected donors -0.01 (p 0.962, n 18). fragile.
- cell type
- strongest in microglia: -0.75 (p 3.1e-4, n 18) vs -0.01 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ZNF638 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up ZNF638 · microglia · braak: substantia nigra, an independent cohort (already registered)
receipt 7989: ZNF638 in oligodendrocytes, braak
- power
- full sample +0.06 (p 0.807, n 18), 95% CI -0.42 to +0.51. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.09 (p 0.709, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.23 (p 0.360, n 18). could be the mix.
- skeptic
- leave-one-out range -0.06 to +0.16, sign flips 4; without severely affected donors +0.06 (p 0.807, n 18). fragile.
- cell type
- strongest in microglia: -0.75 (p 3.1e-4, n 18) vs +0.06 in oligodendrocytes. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ZNF638 in oligodendrocytes.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up ZNF638 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.65 p 0.021 (needs p < 2.7e-4)
Receipts
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