Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in hematopoietic stem cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 15913
Sealed predictions
- ZNF385D in dopamine neurons, braak+0.17 (p 0.663) → +0.77 (p 0.015)receipt 15920
Swarm cases
receipt 15920: ZNF385D in dopamine neurons, braak
- power
- full sample +0.46 (p 0.052, n 18), 95% CI -0.00 to +0.77. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.46 (p 0.052, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.48 (p 0.046, n 18). not the mix.
- skeptic
- leave-one-out range +0.39 to +0.65, sign flips 0; without severely affected donors +0.46 (p 0.052, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ZNF385D in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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