Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.18 (overall 0.11) | 0.18 |
| cell type Human Protein Atlas | group enriched, including oligodendrocyte progenitor cells; strongest in bergmann glia | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2406
Sealed predictions
- ZNF285 in dopamine neurons, braak-0.12 (p 0.749) → -0.29 (p 0.456)receipt 2413
- ZNF285 in oligodendrocytes, braak-0.37 (p 0.324) → -0.02 (p 0.964)receipt 2412
Swarm cases
receipt 2413: ZNF285 in dopamine neurons, braak
- power
- full sample -0.20 (p 0.424, n 18), 95% CI -0.61 to +0.29. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.26 (p 0.298, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.27 (p 0.273, n 18). could be the mix.
- skeptic
- leave-one-out range -0.31 to -0.10, sign flips 0; without severely affected donors -0.20 (p 0.424, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ZNF285 in dopamine neurons.
case closed: nothing better to follow up.
receipt 2412: ZNF285 in oligodendrocytes, braak
- power
- full sample -0.19 (p 0.444, n 18), 95% CI -0.60 to +0.30. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.23 (p 0.360, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.19 (p 0.444, n 18). could be the mix.
- skeptic
- leave-one-out range -0.31 to -0.09, sign flips 0; without severely affected donors -0.19 (p 0.444, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ZNF285 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
loading the receipts