Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in neutrophils | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 45 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 13045
Sealed predictions
- ZDHHC20 in oligodendrocytes, braak+0.45 (p 0.219) → -0.35 (p 0.361)receipt 13052
- ZDHHC20 in dopamine neurons, braak+0.22 (p 0.565) → -0.49 (p 0.183)receipt 13053
Swarm cases
receipt 13053: ZDHHC20 in dopamine neurons, braak
- power
- full sample -0.07 (p 0.774, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.09 (p 0.728, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.02 (p 0.928, n 18). could be the mix.
- skeptic
- leave-one-out range -0.22 to +0.04, sign flips 3; without severely affected donors -0.07 (p 0.774, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ZDHHC20 in dopamine neurons.
case closed: nothing better to follow up.
receipt 13052: ZDHHC20 in oligodendrocytes, braak
- power
- full sample +0.06 (p 0.820, n 18), 95% CI -0.42 to +0.51. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.06 (p 0.820, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.19 (p 0.439, n 18). could be the mix.
- skeptic
- leave-one-out range -0.08 to +0.17, sign flips 4; without severely affected donors +0.06 (p 0.820, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ZDHHC20 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
loading the receipts