Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 6 Parkinson's papers of 96 | 0.74 |
| pathways Reactome | 8 pathways; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 7398
Sealed predictions
- YWHAH in dopamine neurons, braak+0.77 (p 0.015) → +0.33 (p 0.388)receipt 7405
Swarm cases
receipt 7405: YWHAH in dopamine neurons, braak
- power
- full sample +0.41 (p 0.093, n 18), 95% CI -0.07 to +0.73. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.39 (p 0.107, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.36 (p 0.140, n 18). could be the mix.
- skeptic
- leave-one-out range +0.33 to +0.50, sign flips 0; without severely affected donors +0.41 (p 0.093, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for YWHAH in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts