Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 17141
Sealed predictions
- YPEL1 in dopamine neurons, braak-0.07 (p 0.859) → +0.12 (p 0.767)receipt 17148
Swarm cases
receipt 17148: YPEL1 in dopamine neurons, braak
- power
- full sample -0.07 (p 0.774, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.03 (p 0.894, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.07 (p 0.794, n 18). could be the mix.
- skeptic
- leave-one-out range -0.21 to +0.05, sign flips 2; without severely affected donors -0.07 (p 0.774, n 18). fragile.
- cell type
- strongest in oligodendrocytes: -0.59 (p 0.0096, n 18) vs -0.07 in dopamine neurons. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for YPEL1 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up YPEL1 · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.30 p 0.286 (needs p < 1.3e-4)
Receipts
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