parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in vascular endothelial cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 286	0.82
pathways Reactome	1 pathway; mostly immune signalling	0.90

No case: the score is under the bar. Receipt 13170

receipt 13178: XAF1 in dopamine neurons, braak

power: full sample -0.14 (p 0.579, n 18), 95% CI -0.57 to +0.35. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.04 (p 0.867, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.12 (p 0.646, n 18). could be the mix.
skeptic: leave-one-out range -0.28 to -0.01, sign flips 0; without severely affected donors -0.14 (p 0.579, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for XAF1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 13177: XAF1 in microglia, braak

power: full sample -0.07 (p 0.794, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.02 (p 0.935, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.07 (p 0.774, n 18). could be the mix.
skeptic: leave-one-out range -0.13 to +0.08, sign flips 4; without severely affected donors -0.07 (p 0.794, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for XAF1 in microglia.

case closed: nothing better to follow up.

loading the receipts