Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 49 Parkinson's papers of 216 | 0.48 |
| pathways Reactome | 1 pathway; mostly lysosome and autophagy | 1.00 |
No case: the score is under the bar. Receipt 3918
Sealed predictions
- WDR45 in dopamine neurons, braak-0.21 (p 0.581) → +0.53 (p 0.143)receipt 3926
Swarm cases
receipt 3926: WDR45 in dopamine neurons, braak
- power
- full sample +0.10 (p 0.690, n 18), 95% CI -0.38 to +0.54. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.14 (p 0.567, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.22 (p 0.384, n 18). could be the mix.
- skeptic
- leave-one-out range -0.00 to +0.24, sign flips 1; without severely affected donors +0.10 (p 0.690, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for WDR45 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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