parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in cone photoreceptor cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	Reactome did not answer (Reactome: The operation was aborted due to timeout)	0.00

No case: the score is under the bar. Receipt 17028

receipt 17036: VWCE in dopamine neurons, braak

power: full sample -0.36 (p 0.137, n 18), 95% CI -0.71 to +0.12. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.35 (p 0.150, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.51 (p 0.031, n 18). not the mix.
skeptic: leave-one-out range -0.50 to -0.28, sign flips 0; without severely affected donors -0.36 (p 0.137, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for VWCE in dopamine neurons.

case closed: nothing better to follow up.

receipt 17035: VWCE in astrocytes, braak

power: full sample -0.19 (p 0.444, n 18), 95% CI -0.60 to +0.30. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.14 (p 0.585, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.11 (p 0.652, n 18). could be the mix.
skeptic: leave-one-out range -0.34 to -0.10, sign flips 0; without severely affected donors -0.19 (p 0.444, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for VWCE in astrocytes.

case closed: nothing better to follow up.

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