Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.07 (overall 0.05) | 0.07 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.27 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 5 pathways; mostly lysosome and autophagy | 1.00 |
No case: the score is under the bar. Receipt 5470
Sealed predictions
- VPS37A in dopamine neurons, braak-0.02 (p 0.964) → +0.72 (p 0.028)receipt 5478
Swarm cases
receipt 5478: VPS37A in dopamine neurons, braak
- power
- full sample +0.36 (p 0.137, n 18), 95% CI -0.12 to +0.71. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.37 (p 0.132, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.55 (p 0.019, n 18). not the mix.
- skeptic
- leave-one-out range +0.28 to +0.46, sign flips 0; without severely affected donors +0.36 (p 0.137, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for VPS37A in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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