parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.37 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in proximal tubule cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	1 pathway; mostly mitochondrial quality control	1.00

No case: the score is under the bar. Receipt 0772

receipt 0781: VARS2 in dopamine neurons, braak

power: full sample -0.59 (p 0.011, n 18), 95% CI -0.83 to -0.16. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: -0.59 (p 0.0099, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.56 (p 0.017, n 18). not the mix.
skeptic: leave-one-out range -0.68 to -0.53, sign flips 0; without severely affected donors -0.59 (p 0.011, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for VARS2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 0780: VARS2 in astrocytes, braak

power: full sample +0.16 (p 0.521, n 18), 95% CI -0.33 to +0.58. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.16 (p 0.526, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.19 (p 0.460, n 18). could be the mix.
skeptic: leave-one-out range +0.04 to +0.33, sign flips 0; without severely affected donors +0.16 (p 0.521, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for VARS2 in astrocytes.

case closed: nothing better to follow up.

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