Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (rod photoreceptor cells) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 13678
Sealed predictions
- USH2A in dopamine neurons, braak+0.40 (p 0.288) → +0.64 (p 0.065)receipt 13685
Swarm cases
receipt 13685: USH2A in dopamine neurons, braak
- power
- full sample +0.48 (p 0.046, n 18), 95% CI +0.01 to +0.77. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.44 (p 0.064, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.46 (p 0.057, n 18). could be the mix.
- skeptic
- leave-one-out range +0.40 to +0.69, sign flips 0; without severely affected donors +0.48 (p 0.046, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for USH2A in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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