Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 4 Parkinson's papers of 52 | 0.79 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 15382
Sealed predictions
- UBASH3B in dopamine neurons, braak+0.00 (p 1.000) → -0.40 (p 0.292)receipt 15389
Swarm cases
receipt 15389: UBASH3B in dopamine neurons, braak
- power
- full sample -0.15 (p 0.555, n 18), 95% CI -0.58 to +0.34. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.15 (p 0.555, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.17 (p 0.493, n 18). could be the mix.
- skeptic
- leave-one-out range -0.28 to -0.04, sign flips 0; without severely affected donors -0.15 (p 0.555, n 18). fragile.
- cell type
- strongest in microglia: -0.66 (p 0.0030, n 18) vs -0.15 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for UBASH3B in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up UBASH3B · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.63 p 0.026 (needs p < 1.5e-4)
Receipts
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