parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.05 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in oligodendrocytes (108 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 641	0.85
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 5378

receipt 5386: TTL in dopamine neurons, braak

power: full sample +0.01 (p 0.976, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.01 (p 0.976, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.04 (p 0.874, n 18). could be the mix.
skeptic: leave-one-out range -0.12 to +0.12, sign flips 9; without severely affected donors +0.01 (p 0.976, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TTL in dopamine neurons.

case closed: nothing better to follow up.

receipt 5385: TTL in oligodendrocytes, braak

power: full sample -0.17 (p 0.504, n 18), 95% CI -0.59 to +0.32. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.15 (p 0.544, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.16 (p 0.526, n 18). could be the mix.
skeptic: leave-one-out range -0.32 to -0.07, sign flips 0; without severely affected donors -0.17 (p 0.504, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TTL in oligodendrocytes.

case closed: nothing better to follow up.

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