Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.40 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 37 Parkinson's papers of 5,774 | 0.52 |
| pathways Reactome | 11 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 14230
Sealed predictions
- TRIO in dopamine neurons, braak-0.66 (p 0.054) → -0.57 (p 0.109)receipt 14239
Swarm cases
receipt 14239: TRIO in dopamine neurons, braak
- power
- full sample -0.60 (p 0.0089, n 18), 95% CI -0.83 to -0.18. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.56 (p 0.016, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.68 (p 0.0021, n 18). not the mix.
- skeptic
- leave-one-out range -0.68 to -0.54, sign flips 0; without severely affected donors -0.60 (p 0.0089, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TRIO in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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