Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.27 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 10 | 0.91 |
| pathways Reactome | 1 pathway; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 9182
Sealed predictions
- TRAPPC13 in dopamine neurons, braak-0.47 (p 0.197) → +0.04 (p 0.911)receipt 9188
Swarm cases
receipt 9188: TRAPPC13 in dopamine neurons, braak
- power
- full sample -0.26 (p 0.298, n 18), 95% CI -0.65 to +0.24. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.29 (p 0.243, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.31 (p 0.204, n 18). could be the mix.
- skeptic
- leave-one-out range -0.38 to -0.15, sign flips 0; without severely affected donors -0.26 (p 0.298, n 18). fragile.
- cell type
- strongest in OPCs: -0.59 (p 0.0096, n 18) vs -0.26 in dopamine neurons. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TRAPPC13 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up TRAPPC13 · OPCs · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.30 p 0.286 (needs p < 2.3e-4)
Receipts
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