parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in neutrophils	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 223	0.91
pathways Reactome	1 pathway; mostly energy	0.60

No case: the score is under the bar. Receipt 10018

receipt 10026: TPK1 in dopamine neurons, braak

power: full sample +0.39 (p 0.105, n 18), 95% CI -0.09 to +0.73. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.33 (p 0.176, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.34 (p 0.161, n 18). could be the mix.
skeptic: leave-one-out range +0.31 to +0.60, sign flips 0; without severely affected donors +0.39 (p 0.105, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TPK1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 10025: TPK1 in microglia, braak

power: full sample -0.03 (p 0.908, n 18), 95% CI -0.49 to +0.44. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.09 (p 0.715, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.12 (p 0.640, n 18). could be the mix.
skeptic: leave-one-out range -0.14 to +0.07, sign flips 5; without severely affected donors -0.03 (p 0.908, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TPK1 in microglia.

case closed: nothing better to follow up.

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