Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

TOPORS

TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase

translation score 0.51, read 2026-11-01; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocytes; strongest in proximal tubule cells0.75
chemistry
Open Targets		hard to drug0.00
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		1 Parkinson's papers of 840.91
pathways
Reactome		3 pathways; mostly protein handling0.90

No case: the score is under the bar. Receipt 16815

Sealed predictions

  1. TOPORS in dopamine neurons, braak+0.54 (p 0.129) → +0.26 (p 0.493)receipt 16823
  2. TOPORS in oligodendrocytes, braak+0.45 (p 0.222) → +0.55 (p 0.127)receipt 16822

Swarm cases

receipt 16823: TOPORS in dopamine neurons, braak

power
full sample +0.43 (p 0.079, n 18), 95% CI -0.05 to +0.74. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.44 (p 0.064, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.41 (p 0.087, n 18). could be the mix.
skeptic
leave-one-out range +0.34 to +0.58, sign flips 0; without severely affected donors +0.43 (p 0.079, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TOPORS in dopamine neurons.

case closed: nothing better to follow up.

receipt 16822: TOPORS in oligodendrocytes, braak

power
full sample +0.50 (p 0.033, n 18), 95% CI +0.05 to +0.79. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: +0.50 (p 0.033, n 18). holds up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.62 (p 0.0062, n 18). not the mix.
skeptic
leave-one-out range +0.44 to +0.62, sign flips 0; without severely affected donors +0.50 (p 0.033, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for TOPORS in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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