Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.12 (overall 0.10) | 0.12 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 18 Parkinson's papers of 410 | 0.61 |
| pathways Reactome | 2 pathways; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 2545
Sealed predictions
- TOMM40 in dopamine neurons, braak+0.47 (p 0.197) → -0.39 (p 0.304)receipt 2551
Swarm cases
receipt 2551: TOMM40 in dopamine neurons, braak
- power
- full sample -0.09 (p 0.735, n 18), 95% CI -0.53 to +0.40. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.08 (p 0.748, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.27 (p 0.277, n 18). could be the mix.
- skeptic
- leave-one-out range -0.20 to +0.04, sign flips 2; without severely affected donors -0.09 (p 0.735, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TOMM40 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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