Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (late spermatids) | 0.10 |
| chemistry Open Targets | a small-molecule pocket: sapablursen | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 348 | 0.91 |
| pathways Reactome | 2 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 9216
Sealed predictions
- TMPRSS6 in dopamine neurons, braak-0.04 (p 0.910) → -0.69 (p 0.041)receipt 9222
Swarm cases
receipt 9222: TMPRSS6 in dopamine neurons, braak
- power
- full sample -0.29 (p 0.235, n 18), 95% CI -0.67 to +0.20. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.29 (p 0.246, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.47 (p 0.051, n 18). could be the mix.
- skeptic
- leave-one-out range -0.45 to -0.21, sign flips 0; without severely affected donors -0.29 (p 0.235, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TMPRSS6 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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