parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in müller glia	0.75
chemistry Open Targets	reachable by antibody	0.36
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 37	0.91
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 12491

TMEM132A in dopamine neurons, braak-0.25 (p 0.518) → +0.22 (p 0.576)receipt 12500
TMEM132A in astrocytes, braak+0.53 (p 0.143) → -0.54 (p 0.130)receipt 12499

receipt 12500: TMEM132A in dopamine neurons, braak

power: full sample -0.08 (p 0.767, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.08 (p 0.767, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.23 (p 0.369, n 18). could be the mix.
skeptic: leave-one-out range -0.16 to +0.05, sign flips 2; without severely affected donors -0.08 (p 0.767, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TMEM132A in dopamine neurons.

case closed: nothing better to follow up.

receipt 12499: TMEM132A in astrocytes, braak

power: full sample +0.08 (p 0.767, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.06 (p 0.800, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.09 (p 0.722, n 18). could be the mix.
skeptic: leave-one-out range -0.08 to +0.17, sign flips 3; without severely affected donors +0.08 (p 0.767, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TMEM132A in astrocytes.

case closed: nothing better to follow up.

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