Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in alveolar cells type 2 | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 17185
Sealed predictions
- TMEM125 in dopamine neurons, braak+0.03 (p 0.946) → +0.08 (p 0.842)receipt 17193
- TMEM125 in oligodendrocytes, braak+0.42 (p 0.258) → -0.08 (p 0.840)receipt 17192
Swarm cases
receipt 17193: TMEM125 in dopamine neurons, braak
- power
- full sample +0.08 (p 0.761, n 18), 95% CI -0.40 to +0.53. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.13 (p 0.609, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.24 (p 0.346, n 18). could be the mix.
- skeptic
- leave-one-out range -0.04 to +0.25, sign flips 1; without severely affected donors +0.08 (p 0.761, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TMEM125 in dopamine neurons.
case closed: nothing better to follow up.
receipt 17192: TMEM125 in oligodendrocytes, braak
- power
- full sample +0.15 (p 0.555, n 18), 95% CI -0.34 to +0.58. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.11 (p 0.652, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.14 (p 0.585, n 18). could be the mix.
- skeptic
- leave-one-out range +0.06 to +0.31, sign flips 0; without severely affected donors +0.15 (p 0.555, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TMEM125 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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