parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.04 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in microglia (58 nCPM)	1.00
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	9 Parkinson's papers of 319	0.70
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 6184

TMEM119 in microglia, braak-0.20 (p 0.602) → -0.69 (p 0.042)receipt 6190
TMEM119 in dopamine neurons, braak-0.37 (p 0.321) → -0.61 (p 0.080)receipt 6191

receipt 6191: TMEM119 in dopamine neurons, braak

power: full sample -0.53 (p 0.024, n 18), 95% CI -0.80 to -0.08. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: -0.54 (p 0.021, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.75 (p 3.3e-4, n 18). not the mix.
skeptic: leave-one-out range -0.62 to -0.47, sign flips 0; without severely affected donors -0.53 (p 0.024, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TMEM119 in dopamine neurons.

case closed: nothing better to follow up.

receipt 6190: TMEM119 in microglia, braak

power: full sample -0.27 (p 0.277, n 18), 95% CI -0.65 to +0.22. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.24 (p 0.337, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.19 (p 0.439, n 18). could be the mix.
skeptic: leave-one-out range -0.47 to -0.19, sign flips 0; without severely affected donors -0.27 (p 0.277, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TMEM119 in microglia.

case closed: nothing better to follow up.

loading the receipts