parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in hofbauer cells	0.75
chemistry Open Targets	reachable by antibody	0.36
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 9233

TMEM106A in dopamine neurons, braak-0.01 (p 0.982) → -0.66 (p 0.053)receipt 9241
TMEM106A in microglia, braak+0.37 (p 0.334) → -0.50 (p 0.166)receipt 9240

receipt 9241: TMEM106A in dopamine neurons, braak

power: full sample -0.38 (p 0.118, n 18), 95% CI -0.72 to +0.10. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.35 (p 0.153, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.36 (p 0.140, n 18). could be the mix.
skeptic: leave-one-out range -0.55 to -0.31, sign flips 0; without severely affected donors -0.38 (p 0.118, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TMEM106A in dopamine neurons.

case closed: nothing better to follow up.

receipt 9240: TMEM106A in microglia, braak

power: full sample -0.21 (p 0.398, n 18), 95% CI -0.62 to +0.28. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.11 (p 0.658, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.15 (p 0.544, n 18). could be the mix.
skeptic: leave-one-out range -0.37 to -0.09, sign flips 0; without severely affected donors -0.21 (p 0.398, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TMEM106A in microglia.

case closed: nothing better to follow up.

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