parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in neutrophils	0.75
chemistry Open Targets	reachable by antibody: entolimod	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 2,411	0.82
pathways Reactome	4 pathways; mostly immune signalling	0.90

No case: the score is under the bar. Receipt 10791

receipt 10799: TLR5 in dopamine neurons, braak

power: full sample -0.42 (p 0.082, n 18), 95% CI -0.74 to +0.06. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.41 (p 0.091, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.57 (p 0.014, n 18). not the mix.
skeptic: leave-one-out range -0.53 to -0.34, sign flips 0; without severely affected donors -0.42 (p 0.082, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TLR5 in dopamine neurons.

case closed: nothing better to follow up.

receipt 10798: TLR5 in microglia, braak

power: full sample -0.09 (p 0.715, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.09 (p 0.728, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.10 (p 0.696, n 18). could be the mix.
skeptic: leave-one-out range -0.25 to +0.03, sign flips 1; without severely affected donors -0.09 (p 0.715, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TLR5 in microglia.

case closed: nothing better to follow up.

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