Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.24 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 4 Parkinson's papers of 452 | 0.79 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 1739
Sealed predictions
- TKT in dopamine neurons, braak-0.11 (p 0.785) → -0.51 (p 0.163)receipt 1746
Swarm cases
receipt 1746: TKT in dopamine neurons, braak
- power
- full sample -0.51 (p 0.031, n 18), 95% CI -0.79 to -0.06. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.51 (p 0.031, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.48 (p 0.044, n 18). not the mix.
- skeptic
- leave-one-out range -0.59 to -0.46, sign flips 0; without severely affected donors -0.51 (p 0.031, n 18). robust.
- cell type
- strongest in OPCs: -0.64 (p 0.0039, n 18) vs -0.51 in dopamine neurons. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TKT in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up TKT · OPCs · braak: substantia nigra, an independent cohort: not measured
Receipts
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