Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in somatotrophs | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 3 pathways; mostly growth signalling | 0.60 |
No case: the score is under the bar. Receipt 16811
Sealed predictions
- THBS2 in dopamine neurons, braak-0.12 (p 0.756) → -0.59 (p 0.096)receipt 16819
- THBS2 in oligodendrocytes, braak-0.49 (p 0.177) → -0.34 (p 0.373)receipt 16818
Swarm cases
receipt 16819: THBS2 in dopamine neurons, braak
- power
- full sample -0.34 (p 0.173, n 18), 95% CI -0.69 to +0.16. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.34 (p 0.170, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.37 (p 0.130, n 18). could be the mix.
- skeptic
- leave-one-out range -0.47 to -0.24, sign flips 0; without severely affected donors -0.34 (p 0.173, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for THBS2 in dopamine neurons.
case closed: nothing better to follow up.
receipt 16818: THBS2 in oligodendrocytes, braak
- power
- full sample -0.30 (p 0.225, n 18), 95% CI -0.67 to +0.19. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.30 (p 0.225, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.25 (p 0.315, n 18). could be the mix.
- skeptic
- leave-one-out range -0.43 to -0.20, sign flips 0; without severely affected donors -0.30 (p 0.225, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for THBS2 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
loading the receipts