parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.11 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in oligodendrocytes (172 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	157 Parkinson's papers of 2,928	0.33
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 2476

receipt 2484: TFEB in dopamine neurons, braak

power: full sample -0.43 (p 0.072, n 18), 95% CI -0.75 to +0.04. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.48 (p 0.046, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.46 (p 0.057, n 18). could be the mix.
skeptic: leave-one-out range -0.50 to -0.36, sign flips 0; without severely affected donors -0.43 (p 0.072, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TFEB in dopamine neurons.

case closed: nothing better to follow up.

receipt 2483: TFEB in oligodendrocytes, braak

power: full sample -0.44 (p 0.064, n 18), 95% CI -0.75 to +0.03. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.44 (p 0.064, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.44 (p 0.064, n 18). could be the mix.
skeptic: leave-one-out range -0.66 to -0.37, sign flips 0; without severely affected donors -0.44 (p 0.064, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TFEB in oligodendrocytes.

case closed: nothing better to follow up.

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