parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in distal convoluted tubule cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 11963

TBC1D9 in dopamine neurons, braak-0.19 (p 0.630) → +0.33 (p 0.387)receipt 11972
TBC1D9 in microglia, braak-0.22 (p 0.576) → -0.21 (p 0.581)receipt 11971

receipt 11972: TBC1D9 in dopamine neurons, braak

power: full sample +0.05 (p 0.834, n 18), 95% CI -0.42 to +0.51. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.04 (p 0.881, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.08 (p 0.761, n 18). could be the mix.
skeptic: leave-one-out range -0.10 to +0.16, sign flips 5; without severely affected donors +0.05 (p 0.834, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TBC1D9 in dopamine neurons.

case closed: nothing better to follow up.

receipt 11971: TBC1D9 in microglia, braak

power: full sample -0.29 (p 0.235, n 18), 95% CI -0.67 to +0.20. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.25 (p 0.323, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.31 (p 0.207, n 18). could be the mix.
skeptic: leave-one-out range -0.48 to -0.19, sign flips 0; without severely affected donors -0.29 (p 0.235, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TBC1D9 in microglia.

case closed: nothing better to follow up.

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