parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in microglia (305 nCPM)	1.00
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 10	0.91
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 12861

TBC1D12 in dopamine neurons, braak-0.43 (p 0.247) → +0.16 (p 0.685)receipt 12869
TBC1D12 in microglia, braak-0.45 (p 0.230) → +0.08 (p 0.838)receipt 12868

receipt 12869: TBC1D12 in dopamine neurons, braak

power: full sample -0.11 (p 0.671, n 18), 95% CI -0.55 to +0.38. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.06 (p 0.827, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.03 (p 0.901, n 18). could be the mix.
skeptic: leave-one-out range -0.25 to -0.03, sign flips 0; without severely affected donors -0.11 (p 0.671, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TBC1D12 in dopamine neurons.

case closed: nothing better to follow up.

receipt 12868: TBC1D12 in microglia, braak

power: full sample -0.19 (p 0.439, n 18), 95% CI -0.61 to +0.30. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.29 (p 0.246, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.15 (p 0.549, n 18). could be the mix.
skeptic: leave-one-out range -0.32 to -0.07, sign flips 0; without severely affected donors -0.19 (p 0.439, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for TBC1D12 in microglia.

case closed: nothing better to follow up.

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