Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.24 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 1 stopped | 0.60 |
| literature PubMed | 62 Parkinson's papers of 20,678 | 0.46 |
| pathways Reactome | 5 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 12940
Sealed predictions
- TANK in dopamine neurons, braak+0.26 (p 0.493) → +0.53 (p 0.145)receipt 12947
Swarm cases
receipt 12947: TANK in dopamine neurons, braak
- power
- full sample +0.40 (p 0.097, n 18), 95% CI -0.08 to +0.73. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.42 (p 0.080, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.35 (p 0.150, n 18). could be the mix.
- skeptic
- leave-one-out range +0.32 to +0.52, sign flips 0; without severely affected donors +0.40 (p 0.097, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for TANK in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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