Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.10 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in oligodendrocytes (215 nCPM) | 1.00 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 34 Parkinson's papers of 73 | 0.53 |
| pathways Reactome | 2 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 2703
Sealed predictions
- SYT11 in dopamine neurons, braak-0.36 (p 0.341) → +0.47 (p 0.197)receipt 2711
- SYT11 in oligodendrocytes, braak-0.18 (p 0.639) → +0.46 (p 0.212)receipt 2710
In the sealed studies
- The synaptic vesicle cycle in resilient donors: did not hold
Swarm cases
receipt 2711: SYT11 in dopamine neurons, braak
- power
- full sample +0.18 (p 0.482, n 18), 95% CI -0.32 to +0.59. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.15 (p 0.544, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.17 (p 0.509, n 18). could be the mix.
- skeptic
- leave-one-out range +0.08 to +0.30, sign flips 0; without severely affected donors +0.18 (p 0.482, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SYT11 in dopamine neurons.
case closed: nothing better to follow up.
receipt 2710: SYT11 in oligodendrocytes, braak
- power
- full sample +0.15 (p 0.544, n 18), 95% CI -0.34 to +0.58. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.11 (p 0.664, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.05 (p 0.847, n 18). could be the mix.
- skeptic
- leave-one-out range +0.03 to +0.29, sign flips 0; without severely affected donors +0.15 (p 0.544, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SYT11 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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