parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in choroid plexus epithelial cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 16025

STOX1 in dopamine neurons, braak+0.43 (p 0.251) → +0.21 (p 0.591)receipt 16033
STOX1 in astrocytes, braak-0.07 (p 0.857) → +0.15 (p 0.702)receipt 16032

receipt 16033: STOX1 in dopamine neurons, braak

power: full sample +0.24 (p 0.341, n 18), 95% CI -0.26 to +0.63. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.23 (p 0.369, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.09 (p 0.735, n 18). could be the mix.
skeptic: leave-one-out range +0.14 to +0.40, sign flips 0; without severely affected donors +0.24 (p 0.341, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for STOX1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 16032: STOX1 in astrocytes, braak

power: full sample +0.10 (p 0.696, n 18), 95% CI -0.39 to +0.54. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.00 (p 0.997, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.11 (p 0.652, n 18). could be the mix.
skeptic: leave-one-out range +0.00 to +0.19, sign flips 0; without severely affected donors +0.10 (p 0.696, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for STOX1 in astrocytes.

case closed: nothing better to follow up.

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